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Antihistamines treatment for allergic rhinitis: Different routes, different mechanisms?

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Antihistamines have been used in the treatment of rhinitis since ancient times. Antihistamines can be used via oral or topical route for the treatment of allergic rhinitis, as well as nonallergic forms of rhinitis. The topical formulation of medications is the preferred treatment route used for many diseases. This article will investigate the differences in the route of antihistamines in the treatment of allergic rhinitis. A review of the literature was performed to investigate the differences between the use of oral and topical antihistamines in the treatment of allergic rhinitis. Antihistamines inhibit the mediators of inflammation that worsen the symptoms of allergic rhinitis. Intranasal and oral antihistamines are important options in the therapy of allergic rhinitis, and topical use may result in unexpected benefits to patients with allergic rhinitis.

Keywords: Allergic rhinitis; anti-inflammatory; antihistamines; azelastine; intranasal histamines; mechanism of action; olopatadine; rhinitis; route; topical antihistamines

Document Type: Research Article


Affiliations: Miami Children's Hospital, Division of Allergy and Immunology, Miami, Florida, USA.

Publication date: November 1, 2009

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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