Authors: Nelson, Harold S.; Gallegos, Christina M.; Silveira, Lori J.; Newell, John D.; Gelfand, Erwin W.

Source: Allergy and Asthma Proceedings, Volume 30, Number 3, May-June 2009 , pp. 284-292(9)

Publisher: OceanSide Publications, Inc

Abstract:

The inflammation in asthma involves both the large and the small airways. This study was designed to examine whether mometasone delivered from a dry powder inhaler would improve those parameters thought to reflect patency and obstruction of the small airways (diameter <2 mm). Subjects with mild to moderate asthma, only receiving short-acting beta-agonists, underwent baseline assessment, and then were randomized to receive for 12 weeks either mometasone 400 micrograms once daily in the evening or matching placebo. Outcomes assessed included clinical measures and measures of airway responsiveness and inflammation included methacholine sensitivity (concentration of methacholine causing a 20% fall in forced expiratory volume in 1 second [FEV₁] [PC₂₀]), exhaled nitric oxide, serum ECP, and sputum eosinophils. Pulmonary function was assessed by spirometry, plethysmography, and forced oscillometry. Measures of small airway patency included single breath nitrogen washout and air trapping on expiratory high-resolution computed tomography. Results were available on 12 adult subjects who received mometasone and 14 subjects who received placebo. Among tests reflecting small airway patency, the forced expiratory flow between 25 and 75% of vital capacity was significantly improved by mometasone compared with placebo (+9% versus −6%; p = 0.006 and the closing volume over forced vital capacity (FVC; −2% versus 0%; p = 0.05). Other results significantly favoring mometasone over placebo included FEV₁, FVC, PC₂₀, and A.M. and P.M. peak expiratory flows, and albuterol use. Mometasone delivered by a dry powder inhaler improved asthma control and pulmonary function in tests reflecting both large and small airways.

Keywords: Asthma; computed tomography; inflammation; inhaled corticosteroids; mometasone; nitrogen washout; plethysmography; pulmonary function tests; small airways

Document Type: Research article

DOI: http://dx.doi.org/10.2500/aap.2009.30.3235

Affiliations: 1: Department of Medicine, National Jewish Health, Denver, Colorado, USA. nelsonh@njhealth.org

Publication date: 2009-05-01

More about this publication?

• Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.
  
  The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.
  
  Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.
  
  The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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