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Measurement of specific airway resistance decreased the risk of delay in asthma diagnosis in children

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Abstract:

Factors that facilitate the asthma diagnosis in children are still being investigated. We attempted to assess the duration of a delay in asthma diagnosis in children, and we examined the previously identified risk factors of its occurrence together with the pulmonary function test results such as spirometry and specific airway resistance (sRaw) and sought to determine how the measurement of sRaw contributes to asthma diagnosis in children. This study was a part of the Asthma Prevention Study in Poland, which focused on increasing early detection of asthma in a community-based cohort. Data were collected using a questionnaire during regular doctor visits. Childrens' medical documentation from the time period between birth and the visit was analyzed. Participants with the duration of an undiagnosed asthma above the upper quartile range of this variable were defined as having a delayed asthma diagnosis. The independent risk factors of the delayed asthma diagnosis included the absence of atopy, allergic rhinitis symptoms, asthma/allergy in a family, and living in the single-parent families. The whole-body plethysmography performed simultaneously with the spirometry revealed the underestimation of reversibility of bronchial obstruction in 16.4% of participants. This underestimation of reversibility of bronchial obstruction was the only modifiable, independent risk factor of the delayed asthma diagnosis in children. Measurement of sRaw contributes significantly to asthma diagnosis in children at risk of the delayed asthma diagnosis.

Keywords: Asthma prevention; FEV1; children; delayed asthma diagnosis; pulmonary function test; sRaw; underestimation of bronchial obstruction

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/aap.2009.30.3194

Affiliations: Department of Pediatrics and Allergy, N. Copernicus Hospital, Lodz, Poland

Publication date: January 1, 2009

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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