Authors: Huang, Fengyang¹; del-Río-Navarro, Blanca Estela²; Sienra Monge, Juan José Luis²; Torres Alcántara, Saúl³; Pérez Ontiveros, José Alfredo¹; Navarro Olivos, Efraín²; Martínez de Castro, Nut Georgina Toussaint⁴; Zhao, Ling⁵; Hong, Enrique⁶

Source: Allergy and Asthma Proceedings, Volume 29, Number 5, September-October 2008 , pp. 453-460(8)

Publisher: OceanSide Publications, Inc

Abstract:

Asthma and obesity are prevalent disorders, each with a significant impact on the public health. The causality relating obesity and asthma has not been established. The objective of this article is to investigate whether asthma could exacerbate the endothelial activation and to determine the relationship between systemic inflammation and endothelial activation in obese asthmatic children. Eighty-nine children (10-16 years old) were divided according to their diagnosis (asthma, obese nonasthmatic, and obese asthmatic children). Twenty healthy children formed the control group. Three adhesion molecules (E-selectin, sICAM-1, and sVCAM-1) and C-reactive protein (CRP) were measured in serum samples. The levels of sICAM-1 were significantly higher in obese nonasthmatic and obese asthmatic children versus control and lean asthmatic children (414.7 ± 154.7, 434.9 ± 181.1, 238.6 ± 117.8, and 351.2 ± 153.5 ng/mL, respectively). No difference was observed between obese nonasthmatic and obese asthmatic groups. No difference of the levels of CRP, E-selectin, and sVCAM-1 was found among the study groups. Correlation analysis showed that E-selectin associated significantly with body mass index (BMI), CRP and the other two adhesion molecules. CRP depended on BMI. sICAM-1 associated with CRP, BMI, and triglycerides. Correlations were verified in multiple regression analysis models in the whole study groups: CRP levels depended on sICAM-1, E-selectin, and sICAM-1 concentrations depended on BMI. Correlations were verified in asthmatic subjects: CRP depended on sICAM-1. These results confirmed the endothelial activation in obese children. Mild nonallergic asthma in our study did not exacerbate the endothelial activation in obese or lean asthmatic children. Significant association between systemic inflammation and endothelial activation was observed in asthmatic children.

Keywords: Adhesion molecules; asthma; children; C-reactive protein; e-selectin; obesity; sICAM-1; sVCAM-1

Document Type: Research article

DOI: http://dx.doi.org/10.2500/aap.2008.29.3149

Affiliations: 1: From the Department of Pharmacology and Toxicology, 2: Department of Allergy, 3: Department of Immunology, 4: Department of Nutrition, Hospital Infantil de México Federico Gómez, Mexico City, Mexico, 5: Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing, China, and 6: Department of Pharmacobiology, Centro de Investigación de Estudio Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico

Publication date: 2008-09-01

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• Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.
  
  The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.
  
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  The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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• By this author: Huang, Fengyang ;  del-Río-Navarro, Blanca Estela ;  Sienra Monge, Juan José Luis ;  Torres Alcántara, Saúl ;  Pérez Ontiveros, José Alfredo ;  Navarro Olivos, Efraín ;  Martínez de Castro, Nut Georgina Toussaint ;  Zhao, Ling ;  Hong, Enrique

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