Skip to main content

Frequency of S and Z alleles for alpha-1-antitrypsin and tumor necrosis factor alpha −308 promoter polymorphism in northeastern Mexico

Buy Article:

$31.50 plus tax (Refund Policy)

Diseases characterized by airway inflammation, excessive secretion, and obstruction affect a substantial proportion of the population. Studies for understanding the mechanisms underlying these processes are focused on the initiation and maintenance of inflammation. Polymorphisms on DNA sequence of response mediators such as alpha-1-antitrypsin (AAT) and tumor necrosis factor (TNF) alpha have the capacity to influence presentation of diseases, affecting protein amount and/or functionality, and can be analyzed as disease modulators. The purpose of this study was to analyze AAT S and Z alleles and −308G/A TNF-alpha polymorphism on the northeast Mexico mestizo population to compare the influence of these genes in several diseases. DNA samples from 103 volunteers (healthy group) were tested for modifier gene variants by polymerase chain reaction-RFLP as follows: AAT gene for S and Z alleles and TNF-alpha promoter −308G/A (TNF1/TNF2) alleles. Allele frequency for S and TNF2 alleles were 1.5 and 2.4%, respectively, whereas the Z allele was not detected. This study shows low frequencies of the AAT S and TNF2 alleles, and the Z allele was not found. Correlation studies in the future will allow to determine if these alleles have some influence in the clinical presentation of diverse diseases in this group of people.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Data/Media
No Metrics

Keywords: AATS; AATZ; Mexican population; PCR-RFLP; TNF-1; TNF-2; alpha-1-antitrypsin; cytokines; polymorphisms; population genetics; tumor necrosis factor alpha polymorphism

Document Type: Research Article

Affiliations: 1: Biochemistry Department, School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México; Centro de Biotecnología Genómica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Reynosa, Tamaulipas, México 2: Biochemistry Department, School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México 3: Biochemistry Department, School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México; Centro de Biotecnología Genómica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Reynosa, Tamaulipas, México; Centro de Prevención y Rehabilitación de Enfermedades Pulmonares Crónicas (CEPREP), Hospital Universitario Monterrey, Nuevo León, México; Rheumatology Department, Hospital Universitario, Monterrey, Nuevo León, México 4: Centro de Prevención y Rehabilitación de Enfermedades Pulmonares Crónicas (CEPREP), Hospital Universitario Monterrey, Nuevo León, México 5: Rheumatology Department, Hospital Universitario, Monterrey, Nuevo León, México 6: Centro de Biotecnología Genómica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Reynosa, Tamaulipas, México

Publication date: 2008-07-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Information for Advertisers
  • Reprint Requests
  • www.AJRA.com
  • www.AllergyandRhinology.com
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more