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Free Content Addressing steroid phobia: Improving the risk–benefit ratio with new agents

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Inhaled corticosteroids (ICSs) are the preferred first-line preventative therapy for asthma of all severity levels. Although these drugs have been proven efficacious, concerns of adverse systemic affects due to both long- and short-term use continue to limit patient compliance with dosing regimens. Deficits in bone growth, bone density, and hypothalamic–pituitary–adrenal axis function, in addition to cataract formation and elevated intraocular pressure/glaucoma, have been associated with ICS use in some studies. Although some of these studies were flawed, featured drugs that are less commonly prescribed today, or both, adverse effects from chronic ICSs use are still a cause of concern today. Current therapies are designed to be efficacious at minimal doses, limiting potential side effects, increasing adherence, and improving asthma control.

Keywords: Asthma; ICS; bioavailability; childhood; controller medications; corticosteroids; dose; steroid phobia; systemic; treatment

Document Type: Research Article


Affiliations: 1: Juniata College, Huntington, Pennsylvania 2: Division of Allergy, Asthma and Immunology, Department of Pediatrics Allegheny General Hospital, Pittsburgh, Pennsylvania 3: Division of Allergy, Asthma and Immunology, Department of Pediatrics Allegheny General Hospital, Pittsburgh, Pennsylvania; Drexel University College of Medicine, Philadelphia, Pennsylvania

Publication date: July 1, 2008

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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