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Risk factors associated with transient wheezing in young children

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Abstract:

Transient wheezing in young children has been reported to be independent of atopy. Although persistence of early wheezing has been associated with factors related to allergy in multiple studies, transient wheezing has not been similarly studied. The Childhood Allergy Study birth cohort was the source of these data. Transient wheezing was defined as history of wheezing in the past 12 months at ages 1, 2, and/or 4 years, but not at 6 years, and evaluated in relationship to aeroallergen-specific circulating IgE and positive skin testing as markers of an atopic profile. Testing for IgE and skin-prick testing to dust mites, dogs, cats, ragweed, and timothy were performed at the age of 6 years. Other variables in logistic regression analyses were sex; breast-feeding; birth order; parental allergy and smoking history; and household pets, daycare, fever, and antibiotic use in the 1st year of life. Of 372 children, 128 (34.4%) experienced transient wheezing and 175 (47.0%) never wheezed. Atopy was not associated with transient wheezing (adjusted odds ratio for a positive allergen-specific IgE test = 1.2, p = 0.66; skin-prick test = 0.8, p = 0.47). Boys were more likely to be transient wheezers (adjusted relative risk [RR] = 1.7; 95% confidence interval [CI], 1.1–2.8; p = 0.018). Transient wheeze was associated with antibiotic treatment in the first 6 months of life (adjusted RR = 1.6; 95% CI, 1.0–2.6; p = 0.048). We confirm previous observations that transient wheezing in young children is not associated with an atopic predisposition.

Keywords: Asthma; Childhood Allergy Study; IgE; atopy; breast-feeding; children; epidemiology; pediatric allergy; skin-prick testing; transient wheezing

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/aap.2008.29.3089

Affiliations: 1: Departments of Internal Medicine and Pediatrics, Wayne State University School of Medicine, Detroit, Michigan; Allergy and Immunology Section, William Beaumont Hospital, Royal Oak, Michigan, 2: Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Michigan; Center for Allergy, Asthma and Immunology Research, Henry Ford Hospital, Detroit, Michigan 3: Center for Allergy, Asthma and Immunology Research, Henry Ford Hospital, Detroit, Michigan; Section of Allergy and Immunology, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia

Publication date: March 1, 2008

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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