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Sublingual immunotherapy: Dosing in relation to clinical and immunological efficacy

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An increasing number of clinical immunotherapy trials have been published in the United States and Europe. In the allergy community on both sides of the Atlantic, there is a growing interest in obtaining a better understanding of the allergen doses used in these studies. The question of effective allergen dose is particularly important in sublingual immunotherapy, but the effective dose range still is to be determined.

Keywords: Allergen; allergen extract; bronchial provocation; desensitization; dosing; immunoglobulin E; immunoglobulin G4; immunotherapy; rhinitis; sublingual

Document Type: Review Article


Affiliations: Hospital Médica Sur, Mexico City, Mexico

Publication date: 2008-03-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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