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Immunoglobulin E levels in the 1st year of life

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Asthma allergic rhinitis and atopic dermatitis are multifactorial disorders influenced by various familial and environmental factors. The correlation between maternal and fetal immunoglobulin E (IgE) seems to be caused by genetic factors rather than placental transfer. The purpose of this study was to evaluate and quantify the relationship of IgE levels between mothers and their offspring during the 1st year of life. Total serum IgE levels were assessed in 104 healthy pregnant women just before delivery, as well as in 104 newborns in the 1st days of life and then again at 3, 5, 6, 11 and 12 months of age. A serum IgE increase in infants during the 1st year of life is related to maternal serum IgE levels (and may be divided into three classes, according to IgE concentrations of <100, >100, and <260 kU/L), as shown by significant correlation coefficients and regression slopes. Our findings show that IgE levels in infants of mothers who presented serum IgE levels of >100 kU/L exceeded the norm during the 1st year of life, in the absence of overt atopic disease. It seems useful to consider different categories of infants, as a function of their mothers' IgE, to plan a particular follow-up for children in higher risk classes.
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Keywords: Atopy; cohort; infancy; pregnancy; prevention; risk factors; risks of allergy; serial measurements; serum IgE

Document Type: Research Article

Affiliations: 1: Department of Pediatrics, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy 2: Division of Neonatology and Neonatal Intensive Care, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy 3: Department of Obstetrics and Gynaecology, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy 4: Department of Computer Science and Systems, University of Pavia, Italy 5: Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy

Publication date: 2008-01-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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