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Free Content Antihistamines in the pediatric population: Achieving optimal outcomes when treating seasonal allergic rhinitis and chronic urticaria

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Antihistamines are used frequently in adult and pediatric patients as first-line treatment for both allergic rhinitis and urticaria. There are several different antihistamines on the market, generally divided into first- and second-generation products. Although many of these show efficacy, there are significant differences in the side effect profiles of these medications, with resultant differences in their effect on quality of life and other outcomes. Although the most significant differences are between generations, there are considerations even within generations, especially regarding sedation and possible effects on learning. Other than specific situations in which sedation may be a desired effect, the second-generation antihistamines generally are preferred and the risks and benefits of individual drugs within this group need to be considered for each patient's specific circumstances.

Keywords: Allergic rhinitis; antihistamines; chronic urticaria; medications; optimal outcomes; outcomes; pediatric; seasonal

Document Type: Research Article


Affiliations: 1: Division of Allergy, Asthma and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, PA 2: Division of Allergy, Asthma and Immunology, Department of Pediatrics, Allegheny General Hospital, Pittsburgh, PA; Drexel University, College of Medicine, Philadelphia, PA

Publication date: January 1, 2008

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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