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Uteroglobin-related protein 1 gene −112G/A polymorphism and atopic asthma in Sicilian children

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The secretory protein, uteroglobin-related protein 1 (UGRP1), is expressed mainly in the lung and trachea and recently has been implicated in asthma. The −112G to A transition in the promoter was reported to be associated with asthma in the Japanese population. However, this has not been replicated in other studies. The aim of this study was to find the association of the UGRP1 gene polymorphism with atopic asthma in the Sicilian population. We conducted a transmission disequilibrium test (TDT) in 73 trios identified through 113 pediatric patients being treated for asthma. A case-control study also was performed by comparing the 113 unrelated asthmatic children and 230 unrelated healthy Italian subjects (121 children and 109 adults). The −112 G/A polymorphism was genotyped by the polymerase chain reaction–restriction fragment length polymorphism method and direct sequencing. The TDT revealed that the −112A allele was not preferentially transmitted from the parents to asthmatic offspring (chi-square = 3.08; p = NS). Neither the presence of at least one A allele in an individual's genotype (sum of the G/A and A/A genotype) nor the −112A allele was more prevalent among the asthma subjects than among the control subjects. Our results suggest that the −112G/A polymorphism does not play a significant role in the genetic predisposition of the UGRP1 gene in atopic asthma in the Sicilian population.

Keywords: Asthma; atopy; automatic sequencing; bronchial hyperresponsiveness; genetics; polymerase chain reaction; polymorphism; restriction enzyme; transmission disequilibrium test; uteroglobin-related protein 1 gene

Document Type: Research Article


Affiliations: 1: Genetics Unit, Department of Pediatrics, Medical School, University of Messina, Messina, Italy 2: Department of Human Pathology, Medical School, University of Messina, Messina, Italy

Publication date: November 1, 2007

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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