Sublingual immunotherapy-induced IL-10 production is associated with changed response to the decongestion test: Preliminary results

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Abstract:

Sublingual immunotherapy (SLIT) has been shown to be capable of inducing a regulatory T-cell response as evidenced by IL-10 production. Decongestion testing consists of spraying an intranasal vasoconstrictor drug to evaluate the recovery of nasal airflow limitation. The aim of this study was to assess the association of SLIT-induced IL-10 production with nasal airflow recovery after decongestion testing. Nineteen patients with perennial allergic rhinitis (PAR) were studied: 9 patients successfully assumed SLIT for 3 years and 10 patients were considered as control. In vitro IL-10 production was evaluated after SLIT. Rhinomanometry and decongestion testing were performed in all subjects before and after 3 years. After 3 years, SLIT patients showed a significant decrease of nasal resistances (0.048) and reduced response to decongestion testing (p = 0.044 for absolute values and p = 0.0051 for Δ). The comparison with nontreated allergic patients shows significant differences concerning both pretest values (p = 0.02) and Δ percentages (p = 0.00466). In addition, the decrease of nasal airflow resistance values and the percentages of reversibility were significantly associated with IL-10 levels (p = 0.0016 and p = 0.00294, respectively). This preliminary study provides the first evidence of a changed response to decongestion testing after SLIT that is associated with IL-10 production in patients with PAR.

Keywords: Allergic rhinitis; IL-10; SLIT; decongestion test; dust mite; nasal airflow resistance; rhinomanometry; sublingual immunotherapy

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/aap2007.28.3044

Affiliations: 1: From the A.O.U. San Martino, Genoa, Italy, 2: Ospedale Marina Militare, La Spezia, Italy, 3: Istituto Giannina Gaslini, Genoa, Italy, 4: IRCCS San Matteo, Pavia, Italy, and 5: CEBR, University of Genoa, Genoa, Italy

Publication date: September 1, 2007

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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