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Atopic disease, immune system, and the environment

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Raised prevalence of allergic respiratory diseases observed in the last 20 years seems to be associated with changes of environment and lifestyle, which favor a delayed acquisition of Th1 function in childhood. The purpose of this study is to review recent knowledge concerning the developing human immune system and its interaction with external environmental factors for a better understanding of the changing faces of allergic diseases through infancy and childhood in the allergy-prone individual.
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Keywords: Atopic disease; T lymphocytes; TH1; TH2; cytokines; environment; fetal immunity; hygiene hypothesis; infection; intestinal microflora

Document Type: Review Article

Affiliations: 1: Department of Pediatrics, Catania University, Catania, Italy 2: Department of Pediatrics and Microbiology-Immunology, Naples University, Naples, Italy 3: International Center for Interdisciplinary Studies of Immunology, Georgetown University Medical Center, Washington, D.C.

Publication date: 2007-07-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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