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Lung function, asthma paradox, atopy, and risk factors in Mexican spirometry-diagnosed asthmatic patients

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Abstract:

Despite long-term studies, still not much is known about the asthma triggering factors and its sometimes controversial results. Probably one of the major problems of controversy is the lack of specific and accurate diagnosis of this disease. The aim of this study was to assess lung function, atopy, and environmental factors in spirometry-diagnosed asthmatic patients. Time series of daily counts of hospital emergency admissions were constructed for known asthmatic subjects. Spirometry, chest radiograph, arterial gasometry, skin tests, environmental SO2 levels, and climatic parameters were evaluated. Family asthma history was observed in a high proportion of asthmatic patients and it correlated marginally with severity of asthma. A seasonal trend in asthma frequency was recorded and it was more common in the urban area and in those living in the margins of the city. The most frequent asthma type recorded was the severe persistent asthma. More than 50% of subjects had subresponse to bronchodilator; asthma paradox was recorded in 10.8%. Positive skin tests were observed in 36.9% and SO2 levels did not correlate with asthma attacks. Paradox asthma or tolerance may be developed by asthmatic subjects during chronic treatment with short-acting 2-agonists. To avoid side effects and to decrease the morbidity and mortality associated with the usage of antiasthma medications, it is essential to identify quickly those subjects that respond abnormally to the short-acting 2-agonist.

Keywords: Asthma; asthma paradox; beta-adrenergic agonist; bronchospasm; enviromental factors; paradoxical response; pulmonary function test; risk factors; spirometry; tolerance

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/aap.2007.28.2939

Affiliations: 1: From the Depto. de Salud Ambiental, Centro de Investigación Biomédica, Facultad de Medicina de Torreón, Universidad Autónoma de Coahuila, Mexico, and Depto. 2: From the Depto. de Salud Ambiental, Centro de Investigación Biomédica, Facultad de Medicina de Torreón, Universidad Autónoma de Coahuila, Mexico, and Depto. , de Neumología, 3: de Alergología, Centro Médico Nacional UMAE 71, IMSS, Mexico

Publication date: May 1, 2007

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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