Assessment of variable obstruction by forced expiratory volume in 1 second, forced oscillometry, and interrupter technique
Abstract:The aim of this study was to evaluate the presence and the degree of reversible airflow obstruction as detected by forced expiratory volume in 1 second (FEV1), forced oscillometry (FOT), and interrupter technique (resistance measured by the interrupter technique [Rint]) in mild asthmatic children compared with controls. FOT, Rint, and FEV1 were evaluated before and after albuterol (200 g) administered by metered-dose inhaler and spacer in 28 asthmatic children (mean age ± SD, 9.1 ± 1.9 years) and in 20 healthy children (mean age ± SD, 8.5 ± 2.1 years). No correlation was found between FEV1, FOT, and Rint values either before or after albuterol. FOT and Rint values were highly correlated pre- and postbronchodilatation. An improvement in FEV1 ≥ 12% after albuterol was observed in 11 (39%) asthmatic subjects. As suggested using the cutoff value at R6 ≥ 29%, significant bronchodilatation was observed in 20 (71%) children with FOT and using a reduction ≥0.20 kPa or 2 cm of H2O, 22 (78%) subjects showed significant bronchodilatation with Rint. No significant changes were observed after albuterol in controls. FOT and Rint techniques showed a greater sensitivity in detecting reversibility of bronchoconstriction in mild asthmatic patients. Prospective studies are needed to clarify the possible advantages of these findings in mild–moderate asthmatic children.
Document Type: Research Article
Affiliations: 1: From the Department of Pediatrics, Ospedale “G. Rummo,” Benevento, Italy, 2: Department of Pediatrics, University of Verona, Verona, Italy, and 3: Clinic of Pediatrics, Democrition University, Alexandropolis, Greece
Publication date: May 1, 2007
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