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Assessment of variable obstruction by forced expiratory volume in 1 second, forced oscillometry, and interrupter technique

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The aim of this study was to evaluate the presence and the degree of reversible airflow obstruction as detected by forced expiratory volume in 1 second (FEV1), forced oscillometry (FOT), and interrupter technique (resistance measured by the interrupter technique [Rint]) in mild asthmatic children compared with controls. FOT, Rint, and FEV1 were evaluated before and after albuterol (200 g) administered by metered-dose inhaler and spacer in 28 asthmatic children (mean age ± SD, 9.1 ± 1.9 years) and in 20 healthy children (mean age ± SD, 8.5 ± 2.1 years). No correlation was found between FEV1, FOT, and Rint values either before or after albuterol. FOT and Rint values were highly correlated pre- and postbronchodilatation. An improvement in FEV1 ≥ 12% after albuterol was observed in 11 (39%) asthmatic subjects. As suggested using the cutoff value at R6 ≥ 29%, significant bronchodilatation was observed in 20 (71%) children with FOT and using a reduction ≥0.20 kPa or 2 cm of H2O, 22 (78%) subjects showed significant bronchodilatation with Rint. No significant changes were observed after albuterol in controls. FOT and Rint techniques showed a greater sensitivity in detecting reversibility of bronchoconstriction in mild asthmatic patients. Prospective studies are needed to clarify the possible advantages of these findings in mild–moderate asthmatic children.

Keywords: Asthma; FEV1; children; forced expiratory volume; forced oscillometry; interrupter technique; pulmonary function test; spirometry

Document Type: Research Article


Affiliations: 1: From the Department of Pediatrics, Ospedale “G. Rummo,” Benevento, Italy, 2: Department of Pediatrics, University of Verona, Verona, Italy, and 3: Clinic of Pediatrics, Democrition University, Alexandropolis, Greece

Publication date: May 1, 2007

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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