Nasal eosinophils and reversibility to the decongestion test in patients with perennial allergic rhinitis
Authors: Ciprandi, Giorgio1; Cirillo, Ignazio2; Klersy, Catherine3; Tosca, Maria Angela4; Marseglia, Gian Luigi3
Source: Allergy and Asthma Proceedings, Volume 28, Number 3, May-June 2007 , pp. 292-295(4)
Publisher: OceanSide Publications, Inc
Abstract:
Nasal obstruction is sustained by eosinophilic inflammation in allergic rhinitis. The decongestion test consists of spraying an intranasal vasoconstrictor drug to evaluate the reversibility of nasal airflow limitation. The aim of this study was to assess the relationships of both the number of nasal eosinophils and the degree of nasal obstruction symptom with the reversibility of nasal airflow after the decongestion test in patients with perennial allergic rhinitis (PAR). Eighty-three patients with PAR were studied. Total symptom score, sensitization, rhinomanometry, and the decongestion test were performed in all the patients. Using multivariate analysis, the eosinophils number was significantly (and inversely) associated (p < 0.001) with the reversibility of nasal airflow, whereas the nasal obstruction symptom degree was not (p = 0.338). This study provides evidence of a significant association between nasal eosinophils and the reversibility to the decongestion test in patients with PAR.Keywords: Allergic rhinitis; decongestion test; nasal air flow; nasal eosinophils; nasal obstructions; perennial; rhinomanometry; symptom
Document Type: Research article
DOI: 10.2500/aap.2007.28.2962
Affiliations: 1: From the Azienda Ospedaliera Universitaria San Martino, Genoa, Italy, 2: Ospedale Marina Militare, La Spezia, Italy, 3: IRCCS Policlinico San Matteo, Pavia, Italy, and 4: Istituto Giannina Gaslini, Genoa, Italy
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