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Nasal eosinophils and reversibility to the decongestion test in patients with perennial allergic rhinitis

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Nasal obstruction is sustained by eosinophilic inflammation in allergic rhinitis. The decongestion test consists of spraying an intranasal vasoconstrictor drug to evaluate the reversibility of nasal airflow limitation. The aim of this study was to assess the relationships of both the number of nasal eosinophils and the degree of nasal obstruction symptom with the reversibility of nasal airflow after the decongestion test in patients with perennial allergic rhinitis (PAR). Eighty-three patients with PAR were studied. Total symptom score, sensitization, rhinomanometry, and the decongestion test were performed in all the patients. Using multivariate analysis, the eosinophils number was significantly (and inversely) associated (p < 0.001) with the reversibility of nasal airflow, whereas the nasal obstruction symptom degree was not (p = 0.338). This study provides evidence of a significant association between nasal eosinophils and the reversibility to the decongestion test in patients with PAR.
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Keywords: Allergic rhinitis; decongestion test; nasal air flow; nasal eosinophils; nasal obstructions; perennial; rhinomanometry; symptom

Document Type: Research Article

Affiliations: 1: From the Azienda Ospedaliera Universitaria San Martino, Genoa, Italy, 2: Ospedale Marina Militare, La Spezia, Italy, 3: IRCCS Policlinico San Matteo, Pavia, Italy, and 4: Istituto Giannina Gaslini, Genoa, Italy

Publication date: 2007-05-01

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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