Excess dampness and mold growth in homes: An evidence-based review of the aeroirritant effect and its potential causes
Abstract:Exposure to fungi produces respiratory disease in humans through both allergic and nonallergic mechanisms. Occupants of homes with excess dampness and mold growth often present to allergists with complaints of aeroirritant symptoms. This review describes the major epidemiological and biological studies evaluating the association of indoor dampness and mold growth with upper respiratory tract symptoms. The preponderance of epidemiological data supports a link between exposure to dampness and excess mold growth and the development of aeroirritant symptoms. In addition, biological and clinical studies evaluating potential causal substances for the aeroirritant effect, notably volatile organic compounds (VOCs), are examined in detail. These studies support the role of VOCs in contributing to the aeroirritant symptoms of occupants of damp and mold-contaminated homes.
Document Type: Review Article
Affiliations: 1: From the Division of Allergy, Asthma and Immunology, Scripps Clinic, La Jolla, California, and , La Jolla Institute for Allergy and Immunology, La Jolla, California 2: From the Division of Allergy, Asthma and Immunology, Scripps Clinic, La Jolla, California, and
Publication date: May 1, 2007
- Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.
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