Daytime sleepiness and cognitive performance improve in seasonal allergic rhinitis treated with intranasal fluticasone propionate

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Abstract:

Patients with symptomatic allergic rhinitis often complain of daytime drowsiness and impairment in their speed of thinking responses. In this study, we compared subjects with allergic rhinitis treated with intranasal fluticasone propionate or placebo. We measured nasal symptoms, daytime sleepiness, and cognitive performance. Total nasal symptoms (p = 0.002) and nasal congestion (p = 0.003) improved in the intranasal fluticasone propionate group. Concomitantly, daytime sleepiness decreased (p = 0.001) and cognitive performance improved (p = 0.02). The placebo-treated subjects did not show any significant changes. Effective therapy of allergic rhinitis ameliorates the symptoms of daytime sleepiness and decreased cognitive performance.

Keywords: ALLERGIC RHINITIS; CLINICAL TRIAL; COGNITIVE FUNCTION; CONTINUOUS IMPAIRMENT; DOUBLE BLIND; INTRANASAL STEROID; PLACEBO CONTROLLED; SEASONAL ALLERGIC RHINITIS; SLEEP DISTURBANCE; SOMNOLENCE

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/aap.2007.28.2950

Affiliations: Western Sky Medical Research, El Paso, Texas

Publication date: March 1, 2007

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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