@article {Kose:2007:1088-5412:199,
title = "Circulating adhesion molecules in sera of asthmatic children before and after steroid therapy",
journal = "Allergy and Asthma Proceedings",
parent_itemid = "infobike://ocean/aap",
publishercode ="ocean",
year = "2007",
volume = "28",
number = "2",
publication date ="2007-03-01T00:00:00",
pages = "199-203",
itemtype = "ARTICLE",
issn = "1088-5412",
eissn = "1539-6304",
url = "https://www.ingentaconnect.com/content/ocean/aap/2007/00000028/00000002/art00014",
doi = "doi:10.2500/aap.2007.28.2944",
keyword = "ASTHMA, ADHESION MOLECULE, VCAM-1, INHALED STEROID, CHILDREN, P-SELECTIN, ICAM-1",
author = "Kose, Suna and Karaman, Ozkan and Islekel, Huray and Uzuner, Nevin and Babayigit, Arzu and Olmez, Duygu and Altun, Zekiye and Turgut, Sule and Tezcan, Dilek",
abstract = "The aim of this study was to evaluate respiratory function tests, total eosinophil counts, serum immune globulin E (IgE), and serum concentrations of soluble intercellular adhesion molecule (sICAM)1, soluble vascular cell adhesion molecule (sVCAM) 1, and soluble P-selectin (sP-selectin) levels in the children with mild and/or moderate asthma before and 3 months after inhaled steroids and to determine whether adhesion molecule levels showed any difference between asthmatic and healthy children and whether these levels changed with disease activity. A total of 28 children with bronchial asthma and 24 children as a control group were included in the study. All of the patients in the study group were administered inhaled budesonide treatment. The patients were reevaluated 3 months later. Respiratory functions tests were performed and total eosinophil count and serum total IgE level were determined. Serum levels of sICAM-1, sVCAM-1, and sP-selectin were determined and skin-prick tests were performed. Significant difference paralleled to clinical improvement was found in the study group for respiratory function tests, total eosinophil count, serum IgE level, and sICAM-1 levels determined before and after the treatment. However, no significant difference was found for sP-selectin and sVCAM-1 levels before and after the treatment. The higher level of sICAM-1 before the treatment suggests that leukocyte-endothelial adhesion have a role in bronchial asthma, which is an inflammatory airway disease. Reduction in the level of sICAM-1 after the treatment may be related to the decreased inflammation in response to therapy. However, no strong relationships were found between the determinants representing the inflammation and respiratory function tests.",
}