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The role of pulmonary infection in pediatric asthma

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Abstract:

Recently, several authors have documented that respiratory infections may cause wheezing and acute exacerbation of asthma in children. Respiratory syncytial virus infections have been recognized to produce the first episode of wheezing in children who go on to develop chronic asthma. Furthermore, repeated infections caused by other common childhood viral pathogens have been proposed to affect responses of the immune system in such a way as to prevent the onset of allergic diseases and possibly asthma. Recently, it became clear that also infections by intracellular pathogens, such as Chlamydia and Mycoplasma, may cause acute and chronic wheezing in some individuals. In this review we describe the immunologic and clinical implications of the association between respiratory infections and asthma.

Keywords: ASTHMA; BRONCHIOLITIS; CHILDHOOD; CHLAMYDIA PNEUMONIAE; CYTOKINES; INFECTIONS; INTERLEUKINS; MYCOPLASMA PNEUMONIAE; RESPIRATORY SYNCYTIAL VIRUS

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/aap.2007.28.2964

Affiliations: 1: Biomedicina dell'Età Evolutiva, Pediatria "S. Maggiore", University of Bari, Bari, Italy 2: Biomedicina dell'Età Evolutiva, Pediatria "B. Trambusti", University of Bari, Bari, Italy

Publication date: March 1, 2007

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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