What lies beneath the surface of the itch in adults?
Abstract:Pruritus is synonymous with itching. Many medical conditions are complicated by chronic pruritus compromising the patient's quality of life. The majority of pruritic stimuli are transmitted through C fibers into the lateral spinothalamic tract and then into the somatic sensory cortex where the itching is detected. Histamine, substance P, and tumor necrosis factor α play significant roles in the perception of pruritus. Medical conditions in adults with significant pruritus will be defined in this review.
Document Type: Research Article
Affiliations: Allergy and Pulmonary Services, Scott & White Clinic, College Station, Texas, Department of Internal Medicine, Texas A & M University Health Sciences Center, College Station, Texas
Publication date: March 1, 2007
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