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What lies beneath the surface of the itch in adults?

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Abstract:

Pruritus is synonymous with itching. Many medical conditions are complicated by chronic pruritus compromising the patient's quality of life. The majority of pruritic stimuli are transmitted through C fibers into the lateral spinothalamic tract and then into the somatic sensory cortex where the itching is detected. Histamine, substance P, and tumor necrosis factor α play significant roles in the perception of pruritus. Medical conditions in adults with significant pruritus will be defined in this review.

Keywords: ADVERSE DRUG EFFECT; ATOPIC DERMATITIS; C FIBERS; HISTAMINE; INSECT BITE; PRURITUS; PSYCHIATRIC DISEASE; SUBSTANCE P; URTICARIA; XEROSIS

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/aap.2007.28.2942

Affiliations: Allergy and Pulmonary Services, Scott & White Clinic, College Station, Texas, Department of Internal Medicine, Texas A & M University Health Sciences Center, College Station, Texas

Publication date: March 1, 2007

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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