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Chlamydophila pneumoniae infection status is dependent on the subtypes of asthma and allergy

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Abstract:

This study was undertaken to investigate the association of Chlamydophila pneumoniae infection (CPI) with asthma and allergy. One hundred forty-one patients with asthma aged 3–21 years, 125 healthy controls aged 3–21 years, and 62 allergic but nonasthmatic patients aged 4–20 years participated in this study. C. pneumoniae–specific antibodies were measured by ELISA. There were no significant differences in the percentage of patients positive for C. pneumoniae–specific antibodies between the three groups. Significantly more allergic asthmatic patients were positive for C. pneumoniae–specific IgA and IgA + IgG than nonallergic asthmatic patients, and this difference remained significant after adjustment for age and gender: adjusted odds ratio (OR) 5.9 (1.7–26.2) and p = 0.01 for IgA, and OR 5.2 (1.6–25.8) and p = 0.02 for IgA + IgG. The prevalence of the C. pneumoniae–specific IgA and the IgA + IgG positivity also was significantly lower in the nonallergic asthmatic group than in the allergic and control groups (p < 0.005). No food/drug-allergic patient was positive for C. pneumoniae–specific IgA, whereas 41.6% of the inhalative-allergic patients were positive for this antibody (p = 0.002). In our population CPI does not associate directly with asthma and allergy, but chronic or recurrent infection is associated with allergic asthma and inhalative allergy as opposed to nonallergic asthma and noninhalative allergy.

Keywords: ALLERGIC ASTHMA; CHLAMYDIA; CHLAMYDOPHILA PNEUMONIAE; INHALATIVE ALLERGY; NONALLERGIC ASTHMA

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/aap.2007.28.2957

Affiliations: 1: Buda Children's Hospital, Budapest, Hungary 2: Department of Genetics, Cell Biology, and Immunobiology, Semmelweis University, Budapest, Hungary 3: National Center of Epidemiology, Budapest, Hungary 4: Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary 5: Department of Genetics, Cell Biology, and Immunobiology, Semmelweis University, Budapest, Hungary; Immunogenomics Research Group, Hungarian Academy of Sciences, Budapest, Hungary 6: Immunogenomics Research Group, Hungarian Academy of Sciences, Budapest, Hungary; Heim Pál Pediatric Hospital, Budapest, Hungary

Publication date: January 1, 2007

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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