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Sublingual immunotherapy: An update on immunologic and functional effects

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Abstract:

Specific immunotherapy (SIT) is the only treatment capable of modifying the natural history of the allergic subjects. Several aspects of the immunopathological response modified by sublingual immunotherapy (SLIT) have been investigated; the first parameter historically studied was the production of allergen-specific antibodies. An increase of allergen-specific IgG4 and a decrease of IgE may appear after SLIT. A shift from Th2-polarized immune response toward Th1-oriented pattern has been reported after SLIT. More recently, a crucial role for a subpopulation of T cells has been evidenced: T regulatory (T-reg.) cells. Allergic patients have a defect of T-reg cells. SLIT should be able to induce a specific T-reg. response. SLIT is an alternative route of administration for SIT. Recent evidence shows that SLIT is also able to induce a T-reg. response as detected by IL-10 production.

Keywords: EOSINOPHILS; IL-10 PRODUCTION; IMMUNOLOGIC TOLERANCE; REGULATORY T-CELLS; SUBLINGUAL IMMUNOTHERAPY

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/aap.2007.28.2974

Affiliations: 1: University Hospital San Martino, Genoa, Italy 2: DIMI-CEBR, University of Genoa, Genoa, Italy 3: La Spezia Navy Hospital, La Spezia, Italy 4: Pediatric Hospital G. Gaslini, Genoa, Italy 5: Pediatric Clinic, University of Catania, Catania, Italy 6: Department of Pediatrics, Istituto di Ricovero e cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy

Publication date: January 1, 2007

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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