New insights into the pathophysiology of allergic rhinitis

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Abstract:

The immune response to an allergen is dependent on an initial sensitization process, with future exposures triggering a two-part allergic response including an early and a late phase. The process by which an allergen is recognized as such, including which cell types and cytokines are involved in the sensitization process, has become clearer over the last several years. Similarly, the roles of the different preformed mediators responsible for many of the signs and symptoms of the early phase response have been elucidated. Recent work also has shed some light on the multitude of cells and mediators involved in the late-phase reactions, which can lead to priming and long-term inflammation. This article will discuss some of this recent work as well as review the basics behind all of the stages of the allergic response, especially as they apply to the nose and upper airway.

Keywords: ALLERGEN SPECIFIC IGE; ALLERGIC RHINITIS; CYTOKINES; FOXP3; INTERLEUKINS; LATE PHASE ALLERGIC RESPONSE; LEUKOTRIENES; MEDIATORS; NATURAL KILLER T CELLS; REGULATORY T CELLS; TCR GAMMA DELTA CELLS

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/aap.2007.28.2977

Affiliations: Department of Medicine, and Basic Science, University of Missouri–Kansas City School of Medicine, Kansas City, Missouri; Division of Allergy and Immunology, Children's Mercy Hospital, Kansas City, Missouri

Publication date: January 1, 2007

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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