Efficacy and safety of tacrolimus ointment 0.03% treatment in a 1-month-old "red baby": A case report
Authors: Leonardi, Salvatore; Rotolo, Novella; Marchese, Giuseppe; La Rosa, Mario
Source: Allergy and Asthma Proceedings, Volume 27, Number 6, November-December 2006 , pp. 523-526(4)
Publisher: OceanSide Publications, Inc
Abstract:Several trials have indicated that topical tacrolimus is safe and effective for several immunologic-based skin disorders. We report a child <2 months old, who was admitted to our pediatric department because of generalized erythroderma. We started tacrolimus ointment 0.03% therapy by applying the ointment to the skin once daily, on a limited surface of 10 cm2, changing the skin areas only after the disappearance of inflammation. After only one application we observed a marked improvement of the treated area and after another application the localized erythroderma disappeared. We changed the site of application and continued this treatment regime for 4 weeks. After 2 weeks we reduced treatment application once every other day and after an additional 2 weeks we discontinued therapy because of complete resolution of erythroderma. No adverse clinical effect was recorded and tolerance to the treatment was good. We conclude that 0.03% tacrolimus ointment is efficacious and safe even in an infant <2 months of age.
Document Type: Research article
Publication date: 2006-11-01
- Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.
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