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Free Content Idiopathic (autoimmune) chronic urticaria

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A case of idiopathic chronic urticaria (CU) is described briefly. The clinical characteristics, pathogenesis, diagnosis, and management of this disease are discussed followed by clinical pearls and pitfalls for the practicing allergist as well as the immunologist. CU, defined as recurring attacks of hives lasting for >6 weeks, is a common disorder for which the cause is determined in <20% of patients. Although the pathogenesis of idiopathic CU is not certain, the immune dysregulation/disruption causing autoimmunity is blamed. The diagnosis is based principally on the patient's history. Autologous serum skin test possibly should be performed in older children as a screening test for idiopathic autoimmune CU. This test shows the availability of serum IgG autoantibodies directed against the α-chain of FcRI. However, basophil mediator release assay still is accepted as a gold standard. Treatment is aimed first at avoiding underlying causative factors. Medications varying from H1-antihistamines to plasmapheresis as well as immunosuppressive therapies should be considered depending on clinical improvement. Spontaneous resolution of the disease is probable also.

Document Type: Research Article


Publication date: September 1, 2006

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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