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The effect of montelukast on soluble interleukin-2 receptor and tumor necrosis factor α in pediatric asthma

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Abstract:

Proinflammatory cytokines such as tumor necrosis factor (TNF) α and soluble interleukin 2 receptor (sIL-2R) are very important mediators in induction of inflammatory response in lung. The aim of this study was to investigate anti-inflammatory response of cysteinyl leukotriene receptor antagonist montelukast on macrophage and T-cell activation by sIL-2R and TNF-α in mild atopic asthmatic children. Fifteen children with mild-to-moderate atopic asthma and 15 nonatopic children as control, enrolled in the study. Asthmatic children were treated with montelukast, 5-mg tablets, for 1 month. Lung function test forced expiratory volume in 1 second (FEV1) was performed before and after treatment. Serum TNF-α, sIL-2R, and eosinophil cationic protein levels were determined in the control group and in asthmatic children before and after treatment. The mean eosinophil cationic protein value was significantly decreased (33.1 ± 14.8 and 22.2 ± 12.1; p < 0.05) and FEV1 was significantly increased (86.9 ± 20.9 and 102.1 ± 12.7; p < 0.05) after 1 month treatment with montelukast. The mean serum IL-2R levels were significantly higher in the before treatment group than in the after treatment group (1061.9 ± 491 and 794 ± 230.9; p < 0.05) or in control subjects (581.1 ± 123; p < 0.01). The mean serum TNF-α level was higher in the before treatment group than in the after treatment group and control group (7.30 ± 3.93, 5.20 ± 1.46, and 4.95 ± 1.27; p < 0.05). There was a significant correlation between TNF-α and sIL-2R in patients before montelukast treatment (r = 0.674; p < 0.01). This study indicates that montelukast improves clinical parameters and shows anti-inflammatory response by decreasing serum sIL-2R and TNF-αlevels.

Document Type: Research Article

DOI: https://doi.org/10.2500/aap.2006.27.2923

Publication date: 2006-07-01

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  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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