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The natural history of childhood-onset asthma

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A knowledge of the natural history of asthma in first years of life is necessary to establish preventive and therapeutic plans. The aim of this study was to overview the clinical evidence about the natural history of asthma in different pediatric ages, with emphasis on risk factors and prediction indexes. We used the data source PubMed, using a search algorithm selecting for natural history studies of asthma and respiratory allergy in all children to August 2005. A few studies prospectively assessed the natural history of asthma from infancy to childhood to adulthood to mature age. Some risk factors from these studies can be translated into prognostic indexes. The accuracy of such indexes seems skewed toward screening rather than diagnostic ability. Natural history is the basis on which accurate predictors of the persistence of wheezing and asthma can be predicated. In the absence of genetic markers, parental history of asthma, personal history of eczema, and immunologic tests such as serum IgE, peripheral eosinophilia, and serum eosinophilic cationic protein are the better indicators of the development of asthma in infants.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/aap.2006.27.2850

Publication date: May 1, 2006

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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