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Cytokines and soluble intracellular adhesion molecule 1 in the sera of Saudi eczematous children

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Abstract:

We report five children with atopic eczema. The level of soluble adhesion molecules is known to correlate with disease severity. On the assumption that atopic eczema is a T-lymphocyte–mediated inflammatory disease, in this study, we aimed to determine the presence of soluble intracellular adhesion molecule (sICAM) 1 and the release of inflammatory cytokines. The patient sera were used to measure sICAM-1 by enzyme-linked immunosorbent assay, and the concentration of interleukin (IL)-4 and IL-5 in whole blood culture supernatant was determined by a flow cytometry microsphere-based assay. sICAM-1 was dramatically higher in these patients than healthy controls. In addition, the results showed an increase in IL-4 and IL-5 concentration compared with control subjects. In conclusion, these results showed that sICAM-1 expression is important in inflammation of epithelial cells and can be used as a useful parameter in monitoring the disease activity. The study suggests that T-helper cell subset plays an important role in initiating eczematous disease and that additional studies are needed to explore such a role.

Document Type: Research Article

Publication date: 2006-03-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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