Effect of Short-Acting Inhaler 2-Agonists on Serum Cardiac Troponin in Wheezy Infant
Abstract:Cardiac troponin (cTn) is highly specific for myocardial injury. However, effect of 2-agonist therapy on cTn in wheezy infants is unknown. We aimed to assess serum troponin in children with wheezy infant treated by short-acting inhaler 2-agonists. Twenty-four children, under 5 years old, with the diagnosis of wheezy infant with acute exacerbation were enrolled in the study. Subjects were treated three times by a standard dose of nebulized salbutamol (0.15 mg/kg per dose; maximum, 3 mg; Ventolin Nebules Ampule) therapy. The heart rate, respiratory rate, cTnI, creatine kinase (CK), CK-MB levels, and electrocardiogram were measured in wheezy infant before and after 60-minute nebulized salbutamol. In the control group the heart rate, respiratory rate, cardiac troponin I (cTnI), CK, CK-MB levels, and electrocardiogram were recorded at admission. For Seventeen boys (70.8%) and seven girls (29.2%) with wheezy infant, the mean age of the patients was 21.4 ± 18.13 months and for control groups the mean age was 17.28 ± 16.09 months (p = 0.419). There was no significant difference in serum troponin in patients before treatment, after treatment period, and in controls (mean ± SD, 0.049 ± 0.03, 0.043 ± 0.048, and 0.044 ± 0.034, respectively; p = 0.14, p = 0.72, and p = 0.35, respectively). Short-acting inhaler 2-agonists do not influence circulating troponin levels in wheezy infant with acute attack.
Document Type: Research Article
Publication date: 2005-11-01
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