@article {Tran:2005:1088-5412:418,
title = "Susceptibility to mycobacterial infections due to interferon-gamma and interleukin-12 pathway defects",
journal = "Allergy and Asthma Proceedings",
parent_itemid = "infobike://ocean/aap",
publishercode ="ocean",
year = "2005",
volume = "26",
number = "5",
publication date ="2005-09-01T00:00:00",
pages = "418-421",
itemtype = "ARTICLE",
issn = "1088-5412",
eissn = "1539-6304",
url = "https://www.ingentaconnect.com/content/ocean/aap/2005/00000026/00000005/art00019",
author = "Tran, Dat Q.",
abstract = "A case of interferon-gamma (IFN-)/interleukin-12 (IL-12) pathway defect is presented. Pathophysiology, clinical characteristics, diagnostic test, and case management are reviewed. Clinical Pearls and Pitfalls include: (1) A high probability of a defect in the IFN-/IL-12 cascade exists in patients with disseminated or recurrent infection due to poorly pathogenic mycobacteria or systemic infections caused by non-typhi Salmonella species that are persistent and recurrent despite antibiotic therapy. (2) Although less frequent, patients with impaired IFN-/IL-12 mediated immunity are more susceptible to cytomegalovirus, human herpesvirus 8, herpes simplex virus, Listeria monocytogenes, and Histoplasma capsulatum.",
}