Susceptibility to mycobacterial infections due to interferon-gamma and interleukin-12 pathway defects
Author: Tran, Dat Q.
Source: Allergy and Asthma Proceedings, Volume 26, Number 5, September-October 2005 , pp. 418-421(4)
Publisher: OceanSide Publications, Inc
Abstract:A case of interferon-gamma (IFN-)/interleukin-12 (IL-12) pathway defect is presented. Pathophysiology, clinical characteristics, diagnostic test, and case management are reviewed. Clinical Pearls and Pitfalls include: (1) A high probability of a defect in the IFN-/IL-12 cascade exists in patients with disseminated or recurrent infection due to poorly pathogenic mycobacteria or systemic infections caused by non-typhi Salmonella species that are persistent and recurrent despite antibiotic therapy. (2) Although less frequent, patients with impaired IFN-/IL-12 mediated immunity are more susceptible to cytomegalovirus, human herpesvirus 8, herpes simplex virus, Listeria monocytogenes, and Histoplasma capsulatum.
Document Type: Research Article
Publication date: September-October 2005
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