Corticosteroid pharmacokinetic/pharmacodynamic parameters and their relationship to safety and efficacy

$39.50 plus tax (Refund Policy)

Buy Article:


All inhaled corticosteroids (ICSs) exert their pharmacologic effects through the same mechanism. This review examines pharmacokinetic profiles of ICSs to explain the variations in efficacy and adverse effects seen with these agents and identify ideal properties for an optimal ICS. For optimum efficacy and safety, the ideal ICS would have high pulmonary bioavailability with pulmonary activation for targeted delivery, negligible oral bioavailability, high plasma protein binding, rapid systemic clearance, and sustained pulmonary residence to permit once-daily dosing.

Document Type: Research Article

Publication date: September 1, 2005

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Information for Advertisers
  • Reprint Requests
  • ingentaconnect is not responsible for the content or availability of external websites
Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more