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Aquagenic urticaria with extracutaneous manifestations

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Aquagenic urticaria (AU) is a rare form of physical urticaria in which contact with water evokes hives. Extracutaneous manifestations of AU have been described but have not been controlled successfully to date. Selective serotonin reuptake inhibitors (SSRIs) have not been used previously in the treatment of AU. The aim of this study was to describe a case of AU with extracutaneous manifestations, to describe a novel treatment approach, and to review the literature on AU. Our patient presented with urticarial lesions and migraine-like headaches after contact with any type of water. A variety of prophylactic medications including antihistamines, anticholinergics, and SSRIs, were used and, ultimately, were successful in controlling the patient's symptoms. AU is a rare condition that can have extracutaneous manifestations. Multiple classes of medications, including SSRIs, may be necessary in the treatment and prophylaxis of such patients. Additional research is needed into the pathogenesis of AU.

Document Type: Research Article

Publication date: May 1, 2005

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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