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Theophylline Inhibits IntegrinDependent Eosinophil Superoxide Production

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Abstract:

Theophylline has been proposed as a drug that is able to reduce eosinophil activation in asthma. We tested the hypothesis that it can interfere with the integrin-mediated stimulation of eosinophil function. Eosinophils from healthy donors were triggered by monoclonal antibodies to 1- and 2-integrins in the presence of different concentrations of theophylline: 4.3 g/mL (2.4 × 10 −5M) 13 g/mL (7.2 × 10−5M) 26g/mL (1.4 × 10−4M), and 43 g/mL (2.4 × 10−4M), respectively. The level of activation was evaluated by assaying O2 generation. A statistically significant inhibition (p < 0.05) of O2 generation was observed with the different concentrations of theophylline when eosinophils were triggered via very late antigen 4 (VLA-4), lymphocyte function antigen 1 and the common 2-chain. No effect of theophylline on O2 generation was observed in phorbol-myristate-acetate–stimulated eosinophils. These results suggest that theophylline can interfere with the eosinophil activation triggered by ligation of 1- and 2-integrins. This effect of theophylline possibly may play a relevant role in the inhibition of eosinophil infiltration and activation at the sites of allergic reactions.

Document Type: Research Article

Publication date: 2005-01-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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