Approach to therapy in Chronic Urticaria: When Benadryl is not enough
Chronic urticaria is a relatively common disorder in which its management often presents a difficult clinical challenge. Histamine antagonists are the mainstays of therapy, and the secondgeneration antihistamines offer an attractive combination of efficacy, convenience, and lack of side effects. For patients whose symptoms are not controlled by once daily second-generation antihistamines, adjunct therapy with first generation H1-antihistamines, H2-antihistamines, doxepin, or leukotriene modifiers may be effective. Short-term systemic corticosteroids are useful for acute symptom flares but should not be used chronically. For chronically unremitting disease, immunomodulatory agents such as low-dose oral cyclosporine often are useful.
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Document Type: Research Article
Publication date: 2005-01-01
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