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Airway Epithelial Cell Release of Cytokines: Modulation by Various Therapeutic Agents

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The airway epithelial cell plays a central role in asthma pathogenesis and potential remodeling in secreting numerous cytokines, growth factors, chemokines, and nitric oxide. The role of various therapeutic agents on in vivo and in vitro antigen, growth factor, and respiratory syncytial virus-stimulated human small airway bronchial and alveolar epithelial cells will be reviewed. The experimental studies presented here, which used human airway epithelial cell cultures, may identify new therapeutic options in preventing amplified airway inflammation and remodeling in a subset of asthmatic or bronchiolitis patients with an atopic predisposition.

Document Type: Review Article

Publication date: November 1, 2004

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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