Airway Epithelial Cell Release of Cytokines: Modulation by Various Therapeutic Agents
Abstract:The airway epithelial cell plays a central role in asthma pathogenesis and potential remodeling in secreting numerous cytokines, growth factors, chemokines, and nitric oxide. The role of various therapeutic agents on in vivo and in vitro antigen, growth factor, and respiratory syncytial virus-stimulated human small airway bronchial and alveolar epithelial cells will be reviewed. The experimental studies presented here, which used human airway epithelial cell cultures, may identify new therapeutic options in preventing amplified airway inflammation and remodeling in a subset of asthmatic or bronchiolitis patients with an atopic predisposition.
Document Type: Review Article
Publication date: November 1, 2004
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- Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.
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