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Histamine as a Regulator of Allergic and Asthmatic Inflammation

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The immunologic effects of histamine are exerted via the H1 and H2 histamine receptors (H1R and H2R). The effects of histamine include autoinhibition of histamine release from mast cells and basophils, immunosuppression, and the regulation of the activities of cell-mediated immunity (Th1) and humoral immunity (Th2) cells. The asthma phenotype is associated with relative underexpression of Th1 activities and overexpression of Th2 activities. Although the expression of H1R by Th1 cells is greater than the expression of H2R, the actual role of histamine in maintaining a physiological Th1/Th2 ratio and in regulating the expression of the asthma phenotype has not yet been established.

Document Type: Research Article

Publication date: July 1, 2003

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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