Specific Immunotherapy Effect on Interleukin-18 and CD30 Serum Levels in Monosensitized Patients with Rhinitis
Authors: Ariano, Renato; Merendino, Rosario A.; Minciullo, Paolo L.; Salpietro, Carmelo D.; Gangemi, Sabastiano
Source: Allergy and Asthma Proceedings, Volume 24, Number 3, May-June 2003 , pp. 179-183(5)
Publisher: OceanSide Publications, Inc
Abstract:To clarify the immunologic changes associated with specific immunotherapy (SIT), we analyzed interleukin (IL)-18 and CD30 serum levels in a group of patients with allergic rhinitis before and after SIT. IL-18 is a proinflammatory cytokine that plays an important role in the Th1 response. CD30 is a marker of Th2 lymphocytes. We selected 16 healthy donors (HDs) and 16 patients affected by allergic rhinitis, matched for sex and age. Serum IL-18 and CD30 levels were assayed by an immunoenzymatic method. IL-18 serum levels in the patients were lower than in the HDs before SIT (200.69 ± 93.48 pg/mL versus 296.50 ± 66.29 pg/mL; p < 0.05). After SIT, patients showed an increase of serum IL-18 levels (288.69 ± 146.69 pg/mL versus 200.69 ± 93.48 pg/mL; p < 0.05). On the contrary, serum CD30 levels were higher in patients before SIT with respect to HDs (14.78 ± 8.30 IU/mL versus < 1 IU/mL; p < 0.05). SIT caused a decrease of serum CD30 levels in patients who were allergic (5.95 ± 5.70 IU/mL versus 14.78 ± 8.30 IU/mL; p < 0.05). In conclusion, in this study we showed for the first time the shift of IL-18 and CD30 production after SIT.
Document Type: Original Article
Publication date: May 1, 2003
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