Asthma Pathophysiology and the Scientific Rationale for Combination Therapy
The clinical and scientific description of asthma has been undergoing an evolution of continuous revision during the past 10 years. This disorder has been recognized as a complex entity with interplay between genetic, environmental, and allergenic factors resulting in a significant component of inflammation of the airway. Recent directions in therapy differ in taking either the broad-based antagonist or the specific mediator antagonist approach. This review highlights some of the scientific evidence of the operative pathophysiological events and reviews their applicability to the rationale for broad-based combination asthma therapy.
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Document Type: Regular Paper
Publication date: 2002-07-01
The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.
Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.
Articles marked "F" offer free full text for personal noncommercial use only.
The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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