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Viral Infection and Allergy: Lower Airway

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Acute asthma exacerbations in adults and children are triggered commonly by viral upper respiratory infections. The main culprits are respiratory syncytial virus and parainfluenza virus in young children and rhinovirus in older children and adults. Recent investigations in multiple laboratories have increased our understanding of the nature of this relationship. Postulated mechanisms include a viral modulation of airway epithelial and inflammatory cell function with the release of proinflammatory cytokines and mediators, airway microvascular endothelial cell function leading to airway wall edema, airway smooth muscle cell functions, and neural regulation of airway tone via either enhanced parasympathetic efferent neuronal activity, activation of the release of bronchoactive neuropeptides from sensory c-fibers in the airways, or modulation of the influence of the nonadrenergic/noncholinergic neuronal system on airway tone. There also is evidence that rhinoviruses may directly infect the lower airways. These potential mechanisms likely relate to, are superimposed on, and potentiate preexisting inflammatory and immune responses that are characteristic of the atopic asthmatic airway. Undoubtedly, future efforts will be aimed at the prevention of asthma exacerbations via well-targeted and well-conceived strategies for prevention and/or treatment of upper respiratory infections.
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Document Type: Regular Paper

Publication date: 2002-07-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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