Interleukin-16 Network in Inflammation and Allergy
Authors: Conti, Pio; Kempuraj, Duraisamy; Kandere, Kristiana; Di Gioacchino, Mario; Reale, Marcella; Barbacane, Renato C.; Castellani, Maria L.; Mortari, Umberto; Boucher, William; Letourneau, Richard; Theoharides, Theoharis C.
Source: Allergy and Asthma Proceedings, Volume 23, Number 2, March-April 2002 , pp. 103-108(6)
Publisher: OceanSide Publications, Inc
Abstract:Interleukin (IL)-16 is a homotetramer of 14-kDa subunits discovered in 1982 as a T-cell-specific chemoattractant factor. IL-16 plays a role in trafficking of several immune cells and may be a major chemotactic signal for CD4+ cells. Here, we review some of the key biological actions of IL-16. Because this cytokine has been shown to affect the levels of many inflammatory mediators such as histamine, serotonin, regulated upon activation, normal T cell expressed and secreted (RANTES), and monocyte chemotactic protein-1 (MCP-1), and other cytokines such as IL-2, we investigated the effect of IL-16 on control and stimulated human umbilical cord blood- derived cultured mast cells after antigen challenge. We found that human recombinant IL-16 (0.2-200 ng/mL) does not affect either basal tryptase or IL-8 release or that induced by anti-immunoglobulin E activation. In accordance with other data in the medical literature, we conclude that the most important function of IL-16 is the chemoattraction of CD4+ cells.
Document Type: Regular Paper
Publication date: March 1, 2002
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- By this author: Conti, Pio ; Kempuraj, Duraisamy ; Kandere, Kristiana ; Di Gioacchino, Mario ; Reale, Marcella ; Barbacane, Renato C. ; Castellani, Maria L. ; Mortari, Umberto ; Boucher, William ; Letourneau, Richard ; Theoharides, Theoharis C.