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Effects of Air Pollutants on the Allergic Response

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There is strong evidence that the prevalence and severity of allergy are increasing in many areas of the world. Pollutants have been implicated as one of the important factors responsible for these observations because they have been shown to act at multiple steps in the allergic response. They can increase immunoglobulin E (IgE) synthesis and potentiate the specific IgE response to antigens. Pollutants also are capable of inducing a primary specific IgE response to an antigen and increase allergic airway inflammation. In addition, pollutants can induce airway inflammation or cause nonspecific irritation. Pollutants also are capable of modulating the allergenicity of airborne substances, which possibly may promote allergic sensitization.

Document Type: Regular Paper

Publication date: 2002-01-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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