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Future Advances of Immunotherapy

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Allergen immunotherapy, although effective, has been, to a degree, displaced by symptomatic therapy for bronchial asthma and allergic rhinitis. A major reason for its loss of popularity is the prolonged course of the treatment and the occurrence of reactions, both of which are due to the reaction of the allergenic extract with IgE. Thanks to recombinant technology, the possibility exists of modifying the major allergens so that they have reduced reactivity with IgE. Furthermore, the recombinant allergens can be combined with immunostimulatory sequences that favor the transformation from the Th2 phenotype characteristic of allergy to a Th1 cytokine profile. Thus, recombinant technology and new understanding of ways to alter the immune response to allergens promises to make allergy immunotherapy safer and more efficient.

Document Type: Regular Paper

Publication date: July 1, 2001

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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