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An Updated Model of Clinical Asthma

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A model of asthma, based on the Expert Panel Report but updated to allow for the independence of bronchial hyperresponsiveness from airway inflammation, is presented. The updated model of asthma can be summarized: (1) AI = f1(Allergen) – f2(A1); (2) BHR = f3(Allergen) – f4(BHR); (3) PR = f5(AI); (4) Asthma = f6 (A1 + BHR + PR); where AI is airway inflammation, Allergen is sensitization by allergen, BHR is bronchial hyperreactivity, and PR is pulmonary remodeling. The updated model demonstrates that preventing bronchial hyperreactivity will not prevent the lung destruction associated with asthmatic pulmonary remodeling. The updated model of clinical asthma presented here helps to provide a basis for computer simulation of chronic asthma.

Document Type: Research Article


Publication date: 2001-05-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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