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Free Content The Function of Eosinophils

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What is the primary function of eosinophils? Regulatory or anti-inflammatory or pro-inflammatory? Results with IL-5 knockout mice and with IL-5R alpha knockout mice clearly show that (I) eosinophils play key roles as cellular mediators in asthma and allergy, and that (2) IL-5 is necessary for the participation of eosinophils in allergic inflammation (Foster PS et al. J Exp Med 183:195–201, 1996; Tanaka H et al. Clin Exp Allergy 30:874–881, 2000). The results obtained with IL-5 knockout mice and with IL-5R alpha knockout mice can be used to guide and inform asthma and allergy research in humans.

Document Type: Editorial


Publication date: November 1, 2000

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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