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Allergy and Asthma: Classic TH2 Diseases (?)

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Abstract:

More than a decade of cytokine immunology has revealed a central role for pro-allergic TH2-like cytokines in the immune pathogenesis of allergic diseases and asthma. Of these, IL-4, IL-5, and IL-13 are produced mostly by T lymphocytes; more recently, numerous other immune cell types have been found capable of producing these cytokines as well, although their role in mediating atopic disease pathogenesis is less well understood. In contrast, the counterregulatory cytokine IFN- can inhibit both the production and activities of the pro-allergic cytokines; therefore, central to the atopic diseases is a paradigm of cytokine imbalance, with overproduction of the TH2-like cytokines, and a relative deficiency of IFN- production. Intriguing recent evidence is that all humans are TH2-like cytokine "skewed" at birth, due to maternal–fetal immune biology imperatives. However, further investigations suggest that IFN- is likely to be pro-inflammatory in many if not most aspects of chronic allergic inflammation. Therefore, our understanding of these "classic TH2" diseases evolves, with important insights that will serve to optimize therapeutic strategies and investigations in the new millennium.

Document Type: Research Article

DOI: http://dx.doi.org/10.2500/108854100778248881

Publication date: July 1, 2000

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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