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Correlation of Cat-Hair (Fel d1) Prick Skin Test to Airway Response Using a Live-Cat-Room Challenge Model

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The purpose of this study was to document the relationship between prick skin test, airway, and common allergy symptom responses to natural cat exposure. Twenty-nine volunteers with a history of cat-hair allergy and asthma were recruited. Subjects had spirometry and prick skin test with Fel d1 on Visit 1. On Visit 2, subjects had a live-cat-room challenge with airway responses and allergy symptoms monitored. All 29 subjects had a positive skin test (wheal ≥ 4 mm), but only 12 (41%) had a positive airway response (fall in FEV1 ≥ 15%). There was no significant correlation between the fall in FEV1 and wheal size. All symptom scores increased significantly from baseline, but the change was not significantly related to wheal size. In summary, prick skin test response is not a good predictor of airway response or changes in allergy symptoms using the live-cat-room challenge model.
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Document Type: Research Article

Publication date: 1999-11-01

More about this publication?
  • Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.

    The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma.

    Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.

    Articles marked "F" offer free full text for personal noncommercial use only.

    The journal is indexed in Thomson Reuters Web of Science and Science Citation Index Expanded, plus the National Library of Medicine's PubMed service.
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