Desensitization to 5-Fluorouracil

Authors: Eppinger, Thomas; Sperber, Kirk

Source: Allergy and Asthma Proceedings, Volume 20, Number 3, May-June 1999 , pp. 189-191(3)

Publisher: OceanSide Publications, Inc

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Abstract:

Anaphylactic reactions to 5-fluorouracil (5-FU) are uncommon. We report a 40-year-old female with adenocarcinoma of the ovary who had two reactions immediately after being infused with 5-FU. The second reaction occurred despite prophylaxis with steroids and antihistamines. The patient was positive to 5-FU on puncture skin testing even though there was no previous exposure to the drug. We successfully desensitized her to 5-FU using a continuous intravenous protocol with sequential increments in the fusion rates and drug concentrations. This desensitization method may be useful to manage systemic reactions to 5-FU and other drugs.

Document Type: Research article

DOI: 10.2500/108854199778553064

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