Corticosteroid Effects on Cytokines and Chemokines
Cytokines as soluble proteins or growth factors involved in cellular interactions are major contributors to allergic and immune-mediated inflammation. Chemokines are chemoattractive cytokines subdivided into families based on cysteine residues. This review on corticosteroid effects on cytokines and chemokines will consider only a selected number of several of these proteins studied in our division and in other centers. Characteristics of several major cytokines up to IL-15, chemokine targets and the effect of corticosteroids on various cells, cytokines, and chemokines are reviewed. The effect of corticosteroid inhibitors of non-specific endothelial activation, selective activation of VCAM-1 expression, eosinophil priming and chemokine production related to allergic diseases is illustrated. The effect of nasal corticosteroids on IL-1 beta, RANTES, IL-6, and IL-8 is also discussed.
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Document Type: Research Article
Publication date: 1999-05-01
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- Allergy and Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists.
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